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KMID : 0812020080140010018
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Korean Journal of Neurogastroenterology and Motility
2008 Volume.14 No. 1 p.18 ~ p.23
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The Effect of Itopride Hydrochloride on the Gastrointestinal Motility in Postoperative Ileus of Guinea Pigs
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Lim Hyun-Chul
Choi Eun-Ju
Park Hyo-Jin
Lee Min-Goo
Lee Young-Ho
Jun Nu-Lee
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Abstract
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Backgrounds/Aim: Postoperative ileus (POI) is characterized by a transiently impaired propulsive function of the entire gastrointestinal tract which results from activated inhibitory sympathetic neural reflexes in the gut after abdominal surgery. Itopride hydrochloride (itopride) has been known as a gastroprokinetic agent which inhibits acetylcholinesterase and as antagonizes dopamine D2 receptor. The aim of this experiment is to clarify gastrointestinal motility effect of itopride in POI in guinea pigs.
Methods: Open laparatomy was performed on guinea pig to induce POI. Charcoal was administered through orogastric tubes. The distance of charcoal migration from pylorus to the distal intestine was measured after administration of itopride 1, 3, 10, and 30 mg/kg. Additional experiments with infusion of dopamine and atropine was done to investigate its mechanism.
Results: The gastrointestinal transit was significantly decreased in POI group compared with sham operation group. Itopride showed significant increase in the charcoal movement through the intestine compared with the POI group. A combination of dopamine or atropine with itopride displayed considerable decrease in the migration distance compared with that of itopride alone.
Conclusions: POI group exhibited decrease in gastrointestinal motiliy, and conversely, administration of itopride promoted it through anti-dopaminergic and cholinergic mechanism. (Kor J Neurogastroenterol Motil 2008;14:18-23)
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KEYWORD
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Postoperativeileus, Itopridehydrochloride, Gastrointestinaltransit
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